Rhodopsin

2022-04-02: reference:

Rhodopsin #

• Receptor protein involved in visual phototransduction. A pigment found in the rods of the Retina. A GPCR.

*G-protein-coupled receptors are composed of two binding regions: G proteins and β-arrestins. When β-arrestins are bound, receptors internalize (or downregulate). This leaves less receptors available for dopamine to bind to.

• D2 is mediated by β-arrestin - I think Gi G-protein CRs might be the only one with major βγ signaling cascades. Rhodopsin is itself a GPCR.

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