@Regulation of Arcuate Nucleus Synaptology by Estrogen (Leedom et al. 1994)

2022-01-12 links: Estrogen Arcuate Nucleus

@Regulation of Arcuate Nucleus Synaptology by Estrogen (Leedom et al., 1994) #

• The exposure of the male Hypothalamus to high levels of estrogen following a perinatal surge in Testosterone leads to the development ofa pattern of synaptogenesis which does not support an estrogen-induced gonadotrophin surge in the adult.
• Estrogen stimulates endocytosis of areas of postsynaptic membrane that are dense with small intramembranous protein particles, resulting in a reduction in the number of small intramembranous particles.
• The hypothalamic circuits modulated by estrogen have yet to be delineated. However, recent research has shown that GABA, the Monoamines, and several neuropeptides arc participants in the estrogen-sensitive network which regulates GNRH secretion. In this regard, present work shows estrogeninduced changes in GABA and dopamine synapses in the arcuate nucleus.