Rag

2022-06-14: reference:

Rag GTPase #

• Forms heterodimers of RagA/B with RagC/D, withopposite ’loading states’, such that when one is bound to GTP, the other is bound to GDP.
• Mediates Amino Acid-dependent activation of mTORC1. Upon AA binding, Rag complexes with mTORC1 and translocates from the cytoplasm to docking on the lyososome forming Ragulator. At this point, Rheb can bind.
  • Thus, mTORC1 can only be activated under adequate amino acid concentrations.