Prolyl Hydroxylase
2023-03-17:
Prolyl Hydroxylase (Procollagen-proline dioxygenase) #
Not all of them are HIF-induced.
- L-Proline + α-Ketoglutaric Acid + O2 → (2S, 4R)-4-hydroxyproline + Succinate + CO2
HIF-1α-induced #
- HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells
- Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson’s Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function