yana-notes

Peptide 21

2022-03-20: Nootropics reference:

Peptide 21 #

360 Isolated from Cerebrolysin. They found out its effects were thanks to reacting to CNTF. So, they made P6, but it had poor permeability through the BBB (HA-P6 fixes this.) Thus, P21 was born.

  • It is a CNTF memetic essentially with its Neurotrophic Factors properties. Inhibits LIF, which inhibits neural progenitor cell formation.
    • Binds to gp130 and LIFr to alter stat3 signalling to create new neurons Sustained usage reverses Myopia but causes angiogenesis like, on the eyes. It takes a good month to perceive benefits.