Paracetamol

2022-08-02: reference:

Paracetamol #

An NSAID. It inhibits COX-2, and to a lesser extent COX-1. In vitro screens demonstrate a rather low potency on either - influencing TRPV, Cav3.2, nitric oxide, serotonin, and endocannabinoid pathways is more apt description. Estrogenic as well.

• Paracetamol (acetaminophen) use in infants and children was never shown to be safe for neurodevelopment: a systematic review with citation tracking
• Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: the results of a parent survey
• Central dopaminergic system plays a role in the analgesic action of paracetamol: Preclinical evidence
• The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain
  • Paracetamol significantly increased the Serotonin content in the pontine and cortical areas by 75% and 70% respectively.
• Positional isomers of acetaminophen differentially induce proliferation of cultured breast cancer cells
  • Increases breast cancer cell proliferation

AM404 (N-arachidonoylaminophenol) #

Responsible (not solely) for its analgesic and anticonvulsant effects.

• Endocannabinoid reuptake inhibitor? Probably a FAAH inhibitor since it raises Anandamide concentrations in the synaptic cleft.
• Still a COX-1/COX-2 inhibitor. TRPV1 agonist.
• Weak CB1 and CB2 agonist.