Anandamide
022-03-04: reference:
Anandamide (Arachidonoyelthanolamine)
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Yes, Ananda. (Sanskrit ‘bliss’)
- Hence the name, it is synthesized from N-arachidonoyl-Phosphatidylethanolamine.
- Similar pharmacology to THC at CB1 and CB2. I think it has dedicated receptors.
- α7 nAChR inhibitor
- Prefers cholesterol and ceramide to other membrane lipids.
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The “Dark Side” of Endocannabinoids: A Neurotoxic Role for Anandamide
- VR1 vanilloid receptors mediates in part cerebral edema, cell loss, and impairment in long-term cognitive functions.
- Central administration upregulates profinallmatory/microglial responses.
- Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways