PQQ

2022-04-29: reference: https://calypsonaturalclinic.com/your-interstellar-pqq-potent-healing/

PQQ (Pyrroloquinoline quinone) (Methotaxin) #

• Antioxidant. Redox cofactor. Quinone. All 3 of these things seem to go hand in hand:
• Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein
  • PQQ-bound LDH oxidizes NADH. Stimulates LDH (in the way of Lactate → Pyruvate.)
  • Reduced lactate to zero at 100 μM (= 165 mg)? https://raypeatforum.com/community/threads/pqq-inhibits-lactate-formation-increases-lactate-to-pyruvate-conversion-improves-nad-nadh-ratio.37964/post-845267
• PPAR-α activator.
• Activates Ras-Raf-Mek
• Activates AMPK
• Activates DJ-1
• Banned in India for liver toxicity. Not good for the kidneys either.
• Some people proposed it as a new vitamin, since animals raised without any intake of it show developmental abnormalities:
  • Potential physiological importance of pyrroloquinoline quinone (2009)
    • A component of interstellar dust? What the fuck?
  • Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention
    • Data are reviewed that suggest PQQ’s modulation of lactate acid and perhaps other dehydrogenases enhance NAD+-dependent sirtuin activity, along with the sirtuin targets, such as PGC-1α, NRF-1, NRF-2 and TFAM
    • Deficient mice were kyphotic with friable skin and hair loss.
• Doesn’t cross the blood brain barrier.
  • Intranasal may not be the best idea; it tastes spicy, and also makes your tongue bluish. Color varies batch to batch though, apparently, since when reduced oxidized (or maybe reduced) it turns blue. Maybe this is related to the blueness of Methylene Blue? Doesn’t sound like a stretch.

Supplementation #

• ~20mg is about ideal. 40mg is diminishing returns in vivo.
• Everychem: $20 for 2g of disodium salt.
• Lake Avenue = 20x60=$13.7
• Nutricost = 20x60=$18
• NOW = 50x40=$27

• Taken at night, good for dreaming. Sometimes really insane according to some people on Nootopics like Amdu who says it also still feels quite physically restorative despite the weird changes in architecture
• Can cause nausea for some.
• Anecdotes for improved cognitive switching.
• Old Mike: greatly reduced empathy/emotionality for people
• Anedotes of mild bodily euphoria. I concur.