Naltrexone

2022-04-21: Drugs reference:

Naltrexone (Vivitrol) #

• Opioid Receptor partial agonist with something like a 1:6:97 affinity and a 14-29%, 16-39%, 14-25% Emax for μ, κ, δ respectively. This
• Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion -
  • Increases GluR1 Ser845 phosphorylation.
• Possibly toxic

Supplementation #

96% oral absorption. 5-60% bioavailability. Taken in low doses for some reason: “LDN” (~4.5mg)

• High suicide rate in people who took it. Nice