NR3

2023-10-14:

NR3 #

• Only requires Glycine for activation.
• Has a co-agonist site, etc.: Characterization of a Soluble Ligand Binding Domain of the NMDA Receptor Regulatory Subunit NR3A
• Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
• https://penchant.bio/pages/the-nootropic-potential-of-nmda-nr3a-inhibition
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• Not all good:
  • Impaired Social Behaviors and Minimized Oxytocin Signaling of the Adult Mice Deficient in the N-Methyl-D-Aspartate Receptor GluN3A Subunit reversed with . Also bear in mind that KO isn’t equivalent to NAM/antagonism.
  • “Classic neuroprotection vs learning and memory paradox” Pathogenesis of sporadic Alzheimer’s disease by deficiency of NMDA receptor subunit GluN3A
  • This is because it forms a dimer with the Oxytocin receptor
• Genetic Deletion of NR3A Accelerates Glutamatergic Synapse Maturation