Glutamate Carboxypeptidase

2023-05-11:

Glutamate Carboxypeptidase/NAALDase #

• For this whole A. Arnsten/B. Slusher literature, see also dlPFC, mGluR3, Working Memory, and a bit of Cortical Hierarchy, and some 2-PMPA.

• Coded by the gene folate hydrolase 1.
• Zinc metalloenzyme
• 
  • Catalyzes hydrolysis of N-acetylaspartylglutamate (NAAG) -> glutamate + N-Acetylaspartate.
• For those studying neural based diseases, NAAG is one of the three most prevalent neurotransmitters found in the central nervous system
• Noname spammed hella studies on this on Nootopics discord for a few days straight. He was railing amphetamines or something for sure right?
  • Still NAAG’ing After All These Years: The Continuing Pursuit of GCPII Inhibitors
• Association of Missense Mutation in FOLH1 With Decreased NAAG Levels and Impaired Working Memory Circuitry and Cognition
  • Positive association with NAAG and visual memory performance.
  • rs202676_A(AG) strongly associated with IQ.
• Looking for Drugs in All the Wrong Places: Use of GCPII inhibitors outside the brain