GDF11

2023-10-12:

GDF11 (BMP-11) #

• (Growth differentiation factor 11.)
• Member of the TGF-β family (well, all BMPs are cytokines)
• Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system (2019)
  • Able to reduce the levels of AGEs, protein oxidation and lipid peroxidation, and to slow down the accumulation of age-related histological markers. Significantly prevented the decrease in catalase, glutathione peroxidase and SOD activities
  • Later, Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway (2022)
• Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases
• Levels decline with aging; reaching about 0 at 73
  • [GDF11 Protein as a Geroprotector (Khavinson et al. 2016)]
    • This parially explains the benefits of young blood transfusions.
    • Changes activity of p57 and p27 (aka Kip1 aka CDKN1B)
• GDF11 induces mild hepatic fibrosis independent of metabolic health
• Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy
  • Due to the faact it activates mTORC1 (→ repression of TFEB.)