EAAT2

2022-05-26: reference:

EAAT2 #

• Knockout reduced expression increases addictive/drug-seeking behavior and relapse, and impaired LTP and contextual fear conditioning.
• Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke
  • Locared in the ER.
  • EAAT2 requires association with lipid rafts in order to adequately function:
    • Association of Excitatory Amino Acid Transporters, Especially EAAT2, with Cholesterol-rich Lipid Raft Microdomains - IMPORTANCE FOR EXCITATORY AMINO ACID TRANSPORTER LOCALIZATION AND FUNCTION
    • Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: Association of GLT-1 with non-caveolar lipid rafts
      • TGF-α 1 → MAPK and →PI3K increases GLT-1 expression in (non-caveolar lipid rafts) and TGF-α→PI3K downregulates caveolin-1 expression.
      • GLT-1 is located in non-caveolar Lipid Rafts.