DHCR24

2022-12-11:

DHCR24 #

A Δ24-desaturase for all the Bloch pathway Cholesterol precursors:

• [Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-α production and osteoclast formation in response to LPS]
  • LPS->p38 activates seladin-1. Inhibites LPS-induced p38 and TNF-α but not NF-κB.
• Seladin-1 transcription is linked to neuronal degeneration in Alzheimer’s disease
  • Downregulation associated with Tau hyperphosphorylation. Fluctuation in expression was enhanced by AD-associated mutations in presenilin-1 and APP.