Cistanche

2022-07-02: reference:

Cistanche (Desert Ginseng) #

Apparently, Ghengis Khan legit took this every day.

• The action target of the cistanche deserticola extract comprises an insulin receptor InR, an insulin-like growth factor 1 receptor IGF-1R
• Cistanche promotes the adipogenesis of 3T3-L1 preadipocytes
  • Upregulates Bnip3 and PPAR.

Brenden.henry #

It’s cancelled

• Did blood work before and while on cistanche: no difference in test.
• Cistanche can boost testosterone by increasing LH by 10% in serum, 40% in pituitary, and 20% in testes.
• It is also testicular protective against known toxins such as BPA and has shown to reverse damage in the testes from BPA exposure. Boosts sperm count by over 100% and motility by about 50%. Shortens time needed to get an erection and even helps castrated mice achieve erections.
• CYP11A1 MRNA gene expression is upregulated 650%, (cholesterol side chain cleavage), and its responsible for cholesterol conversion into pregnenolone. 100% upregulation in CYP17A1 which helps catalyze pregnenolone to DHEA and then to androstenedione, or can catalyze progesterone to androstenedione, both of which can lead to increases in testosterone and estrone, however CYP17b is upregulated 150% which favors test rather estrone.
• It decreases corticosterones. It also restores Kisspeptin 1 and activates SIRT1 which partly explains the increase in LH.
• It Increases 5-AR2 about 1200% in the liver, and decreases 5-AR 1 in the testes about 40%.
• It is Neuroprotective especially on dopaminergic neurons and could protect against known toxins such as MPP. Increased dopamine. Also increases GDNF NGF BDNF and shows efficacy in treatment of Parkinson’s and Alzheimer’s disease. Several studies show its anti-viral and anti-tumor effects, improved immunity, anti lipid-peroxidation, free radical scavenging, increased glutathione throughout the body. It’s nephroprotective, anti-inflammatory -inhibits cox2, tnf-alpha, IL-1B, IL-6, enhances glycogen storage in muscle and liver of diabetic rat, 50% and 40% respectively, lowers blood pressure slightly.
• Increases Growth Hormone possibly through ghrelin activation, however I am not so sure if thats really the MOA because it doesnt increase my appetite,
• cistanche is questionable based on 1 study showing testicular toxicity at same dosage range as other studies that show increase, and the AR internalization in hypothalamus may potentially adversely effect muscle(but not strength).*

Dose #

• The tincture from Dragon Herbs is the best stuff.