Choline Transporter

2023-01-08:

HACU = rate-limiting step in Acetylcholine synthesis, mediated by ChT. Apparently ChAT and VAChT (vesicular transporter) isn’t a bottleneck?
- Hemichlinium-3 is a popular experimental inhibitor meant to deplete acetylcholine stores.
- HACU enhancers like piracetam and coluracetam mobilize tonic acetylcholine in the hippocampus by increasing phasic release. NGF enhancers increase tonic release. Could have something to do with Dreams enhancement
Na+ and Cl- -dependent.
Meanwhile, the low-affinity transporter is independent of Na+/Cl- and is primarily for Phosphatidylcholine synthesis.
In the human brain microvascular endothelial cells, two systems initiate the choline absorption: CTL1 (choline transporter-like) and CTL2.

yana-notes