Brilliant Blue G

2022-04-27: reference:

Brilliant Blue G #

P2x7 antagonist.

• Completely suppresses Amyloid β-induced neuronal death, while not affecting APP cleavage.
  • via inhibiting the NLRP inflammasome.
• Brilliant Blue G improves cognition in an animal model of Alzheimer’s disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons (2014)
  • Amyloid β-induced loss of filopodia and spine density in cultured hippocampal neurons was prevented… BBG prevents the learning and memory impairment and cognitive deficits induced by the toxicity of soluble Aβ, and improves the development of dendritic spines in hippocampal neurons in an Alzheimer’s model mouse.