BHLHE41
2023-08-24:
BHLHE41/DEC2/SHARP1 #
- Expressed in the Suprachiasmatic Nucleus and peaks during the day.
- Related to maturation of T helper cells/other immune stuff.
- Induced by HIF-1α and SREBP-1.
- BHLHE40 and BHLHE41 are also known to alter the expression of several contractile proteins and mitochondrial proteins in skeletal muscle. BHLHE41 and BHLHE40 also repress SREBP-1. This forms a negative feedback loop between SREBP-1, BHLHE40, and BHLHE41 in muscles that runs on a 24-hour circadian cycle, which has a 12-hour offset between SREBP-1 and BHLHE40/BHLHE41. In addition, BHLHE41 is known to inhibit inflammation and adipogenic differentiation in muscles.
- Inhibits MyoD and SREBP-1.
- Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex
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DEC2 modulates orexin expression and regulates sleep
- rs121912617 weakens its ability to repress MyoD—this leads to more orexin, and thus people report no effects of sleep deprivation from 6.5 hours of sleep or so (1 less cycle I suppose)