Atomoxetine

2022-08-10: reference:

Atomoxetine (Strattera) #

• NET inhibitor. The thing about this is that NET is responsible for Dopamine reuptake in the Prefrontal Cortex (where DAT expression is minimal) rather than striatum/NAcc like traditional stims.
• NMDA antagonist (to some extent). Possible μ antagonist? Yeah, I think it has some off-target effects. Liver toxic. How fun. See Reboxetine instead. Compare to Guanfacine.
• Altered gene expression in the prefrontal cortex of young rats induced by the ADHD drug atomoxetine (Lempp et al.)
  • 
    • I can only assume the Electron Transport Chain Complex III upregulation is fantastic. It is inhibited by Methylphenidate in adult, but not young rats!
      • Effect of Acute and Chronic Administration of Methylphenidate on Mitochondrial Respiratory Chain in the Brain of Young Rats (Fagundes et al. 2010)
        • I and III were not affected. Acutely decreased I activity in PFC/Cerebellum. Across the board everything slightly decreased but not “significant” enough.
    • Chronic administration of methylphenidate activates mitochondrial respiratory chain in brain of young rats (Fagundes et al. 2010)
• Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect
• Sub-chronic exposure to atomoxetine up-regulates BDNF expression and signalling in the brain of adolescent spontaneously hypertensive rats: Comparison with methylphenidate

Dosing #

Taper up slowly. NET inhibition is hypertensive. Don’t give yourself Raynauds or negative bone effects.

• Weird urinary tract side effects?