Alpha-GPC

links: reference: 10-18-2021

Alpha-GPC (L-Alpha glycerylphosphorylcholine) #

• Precursor of Acetylcholine.
• 40% of it by weight is Choline; it is converted through hydrolysis in the gut mucosa.
• Rapidly delivers Choline across the BBB.
• Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years (2021)

  • 12 million individuals over 50 years. Those prescribed Alpha-GPC in 2006-2008 were assessed for strokes in 2009-2018. The risk factor was calculated to be 46%.

• 19x Increase in Growth Hormone 60min After Ingestion of 1g of Glycerophosphocholine (GPC) in Young Male Subjects WTF?
  • Via acetylcholine decreasing the concentration of somatotropin release-inhibiting factors in the hypotalamus, disinhibiting GH production.
  • α2 Adrenergic Receptor antagonism blocks this.

Supplementation #

Some studies did several grams (split throughout the day)