DISC1

2023-03-18:

DISC1 (Disrupted-in-schizophrenia 1) #

• Sequesters PDE4B (PDE4D to a lesser extent?), releasing it/upregulating under conditions of high cAMP production, by dissociating it from SER.
• DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling unless I’m dumb I don’t think there’s a direct link. It’s just an idea.
• Interacts with D2, and there are peptides that inhibit this.
  • Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors