5-HT4

links: reference: 10-4-2021

5-HT4 #

Increases Estrogen receptors and irritable bowel syndrome (increases acetylcholine)

• 5-HT4 Receptor Agonist Effects on Functional Connectivity in the Human Brain: Implications for Procognitive Action
  • Prucalopride. Gintrux shared an anecdote where a 1mg pill caused insane diarrhea and subsequent nausea/draining of electrolytes or something
    • Lots of receptors in the Gut. Somehow no adverse effects in this study though?
  • Prucalopride: Decreased Default Mode Network activity, increased attention and executive function.
  • Agonism reduces food intake via PFC top-down control/mesolimbic circuit inhibition