Vesicle
2023-06-20:
Synaptic Vesicle #
- Must contain transport proteins for both their intitial uptake and exocytosis.
- ‘Purified vesicles have a protein:Phospholipid ratio of 1:3 with a lipid composition of 40% Phosphatidylcholine, 32% Phosphatidylethanolamine, 12% Phosphatidylserine, 5% Phosphatidylinositol, and 10% Cholesterol.’
- Maintains an acidic environment, preventing oxidation. I think it’s something like 5.5? Mediated by ATPase.
| Neurotransmitter type(s) | Inward movement | Outward movement |
|---|---|---|
| norepinephrine, dopamine, histamine, serotonin and acetylcholine | neurotransmitter+ | 2 H+ |
| GABA and glycine | neurotransmitter | 1 H+ |
| glutamate | neurotransmitter− & Cl− | 1 H+ |