TAK-915

d2022-12-22: Nootropics

TAK-915 #

PDE2A inhibitor.

• TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models
• Inserts AMPA to cell surface, resulting in NMDA activation, Potentiates D1-stimulated dopaminergic function, Activates the PFC, Is the PDE isoform most associated with intelligence
• Enhances GluR1 surface levels on MSN.
• Not in the Everychem pipeline anymore since it didn’t improve learning, plus possible off-traget effects