PDE2 2022-08-23: reference: PDE2 # As cAMP goes up, cGMP binds to pde2 allosteric site and stimulates catalytic breakdown of cAMP by up to 5 fold and also inhibits PKA in D1 MSN’s. So, PDE2 inhibition keeps cAMP and cGMP levels high. Backlinks Hesperetin PDE1 TAK-915 Interactive Graph