SHP

2023-05-21:

SHP (Small heterodimer partner) #

• Inhibits CYP7A1, specifically by inhibiting the activity of the nuclear receptor LRH-1 on the CYP7A1 promoter.
• Also inhibits LXR to induce SREBP-1c to inhibit CYP7A1?
• Inhibits the ligand-dependent transcriptional action of RXR/retinoid receptors and Thyroid Hormone Receptors. Estrogen receptors too.