Pitolisant

2022-09-22: Drugs

Pitolisant #

• H3 partial inverse agonist or something.
• Cholinergic (according to Swiss)
• Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness
• ‘Non-inferior’ to Modafinil at treating narcolepsy.
• Blocks hERG (Kv 11.2)
• Pitolisant-supported bridging during drug holidays to deal with tolerance to modafinil in patients with narcolepsy reverses Modafinil tolerance! Tf?

Dose #

• No tolerance according to Swiss.