Papaverine

2023-03-26:

Papaverine #

Selective PDE10A inhibitor. TAK-063 is also one

• Long-term D2 antagonism would increase supersensitivity, but PDE10Ais prevents this.
• Inhibition of phosphodiesterase 10A has differential effects on dopamine D1 and D2 receptor modulation of sensorimotor gating
• Phosphodiesterase 10A inhibition is associated with locomotor and cognitive deficits and increased anxiety in mice
  • Machine: This flawed study could be infact due to papaverine off target effects. I think it hits noiciceptin receptor or something. It is in fact procognitive:
    • Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents
    • PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington’s disease mouse model
• Neurogenic component in the effect of papaverine, drotaverine and bencyclane
• Inhibited conditioned avoidance behavior

Dose #

Actually sold on bgpharm: https://www.bgpharmadrugs.com/product/papaverine-sopharma-20-mg-ml-solution-for-injection-10-ampules/