PDE10A

2023-03-26:

PDE10A #

• Increase is implicated in ASD-associated neuro-behavioral alterations (impaired plasticity, repetitive behavior, impaired social behavior)
• Alteration has been shown to affect p-CREB and BDNF in huntington’s.
• Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function
  • PDE10A: reducing the sensitivity of medium spiny neurons to glutamatergic excitation
• PDE10A Inhibitors—Clinical Failure or Window Into Antipsychotic Drug Action?
  • Increases substance P and enkephalin mRNA in striatum… PDE10A functions as a brake on a complex transcriptional program in direct and indirect pathway MSNs, indicating that inhibitors of the enzyme may have long term consequences to the function of these neurons