Pannexin
2022-12-07:
Pannexin (Panx1) #
An innexin. There is PANX1 and PANX2. Ca2+-gated ATP export channel.
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Pannexin channels are not gap junction hemichannels
- The functional role for pannexons is different from the connexons. Many pannexin publications have used the term “hemichannels” to describe pannexin oligomers while others use the term “channels” instead... they function not as intercellular channel in appositional membranes.
- I guess that is to say - they are only export channels?
- The functional role for pannexons is different from the connexons. Many pannexin publications have used the term “hemichannels” to describe pannexin oligomers while others use the term “channels” instead... they function not as intercellular channel in appositional membranes.
- Formation of such intercellular (gap junction) channels by Panx1 in mammalian cells is unlikely given the presence of a glycosylation site in the extracellular docking domain of this protein, unlike the low degree of such seen in xenopus oocytes when overexpressed.