PTP1B

2022-09-03: reference:

PTP1B (Protein Tyrosine phosphatase 1B) #

• Dephosphorylates phosphotyrosine residues of the activated Insulin Receptor kinase (the autophosphorylating protein residue or something?)
• Other substrates includes other RTKs like IGF, c-Src, JNK, β-Catenin, I think TrkB, etc.
• Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders (inhibiting it, that is)
  • Inhibition prevents Microglial activation
• Brilliant Blue FCF and claramine are inhibitors.