PSD-95
2022-04-27: reference:
PSD-95 (Postsynaptic density protein 95) #
AKA DLG4 (there is 1-3, 5)
Has 3 PDZ domains. These first two bind to the NMDA’s C-terminus.
- Overexpression occludes LTP and enhanecs LTD in the cerebral cortex and hippocampus.
- PSD-95 overexpression in hippocampal slices enhances specifically synaptic AMPAR-mediated response without changing the number of surface AMPAR. Conversely, Stargazin overexpression increases selectively the number of eAMPAR without changing AMPAR-mediated synaptic currents. These observations indicate that the Stargazin/PSD-95 interaction is involved in the stabilization of AMPARs at synapses. R