Notch

2022-09-10:

Notch #

I wanted to make a minecraft reference but it’s too cringe. Pretty sure its principal action is initiating proliferation.

• Role of Notch Signaling Pathway in Glioblastoma Pathogenesis

  • notch-pathway.png]] #

    • Cleaved successively by ADAM17 and γ-Secretase to yield the intracellular domain (NICD), the active form of notch? It translocates to the nucleus for its transcriptional activity.
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  • Somehow stimulated by eNOS.
• Notch1 inhibited by mTOR.
• Inhibited by Numb.
• Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation