Na+K+ ATPase
links: Enzyme reference: 6-12-2021
Na+/K+-ATPase or Sodium-Potassium Pump #
Sodium-potassium adenosine triphosphatase. Gilbert Ling says it’s fake news.
- Uses the energy of ATP hydrolysis to actively transport, in each cycle, 3 Na+ out of the cell, and 2 K+ into it.
- In most neurons, the concentration of K+ is higher inside, and Na+ is higher oustide.
I’m hearing multiple stories here… Wikipedia, which cites Guyton (2006) has a different order. Gilbert - help me out.
- 3 $\ce{Na+}$ ions bind, by which a conformational change occurs where ATP binds to it, and hydrolyzes.
- The affinity changes from Na+ to K+. the 3 $\ce{Na+}$ dissociates into the extracellular fluid, and 2 $\ce{K+}$ binds.
- The bound phosphate dissociates, and the pump reverts to the original conformation whereby 2 $\ce{K+}$ dissociates into the cell interior.