NCOA4

2022-12-10:

NCOA4 (Nuclear receptor coactivator 4) #

• AKA androgen receptor activator (ARA70)!
• Interacts/coimmunoprecipitates with PPAR-γ.
  • Identification of ARA70 as a Ligand-enhanced Coactivator for the Peroxisome Proliferator-activated Receptor γ
    • PPARγ and ARA70 interact in the absence of the PPARγ ligand 15-deoxy-Δ12,14-prostaglandin J2, although the addition of exogenous ligand enhances this interaction. Androgen receptor squelches (WTF? - halts) PPARγ-ARA70 coactivation.