Myricitrin

2024-02-23:

Myricitrin #

• Myricitrin - a flavonoid isolated from the Indian olive tree ( Elaeocarpus floribundus) - inhibits Monoamine oxidase in the brain and elevates striatal dopamine levels: therapeutic implications against Parkinson’s disease
• Myricitrin Ameliorates Hyperglycemia, Glucose Intolerance, Hepatic Steatosis, and Inflammation in High-Fat Diet/Streptozotocin-Induced Diabetic Mice
  • lowered glucose-6-phosphatase and phosphoenolpyruvate carboxykinase mRNA expression and activity in the liver
  • liver weight, hepatic triglyceride content, and lipid droplet accumulation were markedly decreased
  • decreased fasting blood glucose levels, improved glucose intolerance, and increased pancreatic β-cell mass
• Converts Type II Muscle fibers to Type I: “Biqi” Bayberry Extract Promotes Skeletal Muscle Fiber Type Remodeling by Increasing Fast Myofiber Formation via the Akt/FoxO1 Pathway in Mice
  • The mechanism really isn’t known. It should be pretty potent, considering the presence of myricetin/PGC-1α is acting in the opposite direction.
• Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models
• Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice
  • Hepatic oxidative stress was reduced by myricitrin, as evidenced by the decrease in lipid peroxidation, with concomitant increase in GSH level and CYP2E1 expression.
  • COX-2 and TNF-α overexpression in the liver was reduced, suggesting the suppression of inflammation. The expression of TGF-β1 and alpha-smooth muscle actin (α-SMA) was markedly ameliorated, indicating the inhibition of profibrotic response. Myricitrin also improved the regeneration of hepatic tissue after CCl4-intoxication, as evidenced by increased proliferating cell nuclear antigen (PCNA) expression.

• Myricitrin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation and migration through suppressing PDGFRβ/Akt/Erk signaling #