Methyglyoxal

2022-12-08:

Methyglyoxal (Pyruvaldehyde) #

• Formed via Lipid Peroxidation, or nonenzymatic phosphate elimination from Glyceraldehyde 3-Phosphate. Broken down via Glyoxylase I into Lactoylglutathione → D-Lactate via Glyoxylase II.
• Reacts with Lysine and Arginine’s amino groups, and with Cysteine thiol groups to form AGEs (advanced glycation end products.):
  • Arginine is the most common amino acid found in the catalytic domains on enzymes?
• Damages LDL; it is found in higher concentrations in diabetes. It binds to Nerves endings, directly contributing to diabetic neuropathy.
• It might be cancerostatic? Szeng-Györgi was a fan, I think.