Metformin

2022-02-19 links: reference:

Metformin #

• AMPK activator, by means of inhibiting Complex I, mimicking caloric restriction. It’s fucked. Blocks uptake and lowers ATP production.
  • So yeah - lactic acidosis.
• Decreases bactieral TMA/TMAO production. R
• Decreases testosterone significantly in men and women
• May not be all bad https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8400152/#sec3-nutrients-13-02873title
• Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials
• Lokzo is a fan for whatever reason. Claims it got him shredded af.