Klotho

2022-05-16: reference:

Klotho #

Κλωθώ: one of the three goddesses that controls the thread of life. Transmembrane enzyme. Binds to FGFR.

• α-Klotho: Brain and liver. Activates FGF23.
• β-Klotho: Liver. FGF15/19 & FGF21.
• γ-: Skin.
• Life extension factor klotho enhances cognition
  • Increased serum klotho in transgenic mice increasd net NMDAR subunit, especially NR2B , and NR2B blockade abolished klotho-mediated effects (on cognition). It enhanced cognition even in young (3-4 m.) mice