Indolepropionamide

2022-08-22: reference: https://www.sciencedirect.com/topics/medicine-and-dentistry/indolepropionic-acid

Indolepropionamide #

Produced by Tryptophan by the gram-positive Clostridium sporogenes in the GI.

• 3-indolepropionic acid shares a structural homology and has similar antioxidant properties. Its benzene on the indole is just rotated once to the left.
  • The gut metabolite indole-3 propionate promotes nerve regeneration and repair
    • Inhibited Neutrophil chemotaxis. Mitochondrial Antioxidant. Binds to the rate-limiting component of OP in Complex I.
• A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan
• Indole propionic acid induced Ca 2+ -dependent apoptosis in Candida albicans

Dosing #

~3-5mg.

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