Ganglioside

2022-08-10: reference:

Ganglioside #

• (M = monosialic, where 1, 2, 3 = its order of discovery or something:
• A Glycosphingolipid with 1+ Sialic Acids linked on the sugar chain.
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  • Required synthetic genes depicted in red on the top. There are like 100 different structures but these are the most prominent (by %). The biological properties are, as you might assume, most influenced by the oligosaccharide group.
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• 10% of the Brain lipid mass. The concentration increases approximately three times from the 10th gestational week to the age of about 5 y. Ganglioside GM1 and GD1a increase 12–15 times during the same period. GT1b is the major ganglioside during the third to fifth gestational month, thereafter its concentration drops rapidly to term, and then increases again up to 50 y of age.
  • There are also regional differences in these patterns (by that I mean nations) but as well as brain cell types.
• GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration
• Cholera toxins only binds to/enters cells with GM1 on their surface.