GAP43

2023-05-17:

GAP43 (Growth-associated protein) #

• AKA Neuromodulin, protein F1, calmodulin-binding protein P-57, and some other stuff.
• Expressed at high levels in Growth Cones during development. Null mutation = death due to axon pathfinding defects.
• Association of CSF GAP-43 and APOE ε4 with Cognition in Mild Cognitive Impairment and Alzheimer’s Disease CSF GAP-43 level was significantly increased in MCI ε4+, AD ε4- and AD ε4+ groups compared with CN ε4- or MCI ε4- group.