Etifoxine

2022-08-06: reference:

Etifoxine #

• GABA-A modulator and stimulator of neurosteroids (TSPO agonist) It has multiple effects. Might be hepatotoxic/straining but Swiss says it’s cap and had no effect on liver enzymes for a whole year of usage. Always dosed with melatonin, because somehow that mitigates it. Maybe just antioxidant reasons.
• The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis
  • *Exposure of frog hypothalamic explants to graded concentrations of etifoxine produced a dose-dependent increase in the biosynthesis of 17α-Hydroxypregnenolone, DHEA, Progesterone and tetrahydroprogesterone, associated with a decrease in the production of 5α-DHP.
• Raises serum Testosterone significantly

Dose #

• Anecdotes: 50-100 mg is anxiolytic but not quite sedating until ~150mg.
  • And lower doses are probably more testosterone-increasing rather than neuresteroids and decreasing testosterone in the 300mg+ range.