Egr

2022-05-18: reference:

Early growth response protein 1 (Egr-1) / (NGF-induced protein A (NGFI-A)) #

• Induced by growth factors, cytokines, stress signals, mechanical stress.
• Has three Zinc finger motifs, thus
• Global deletion of Egr-1 results in reduced growth rate of mice.
• Major transcriptional factor for PTEN. R
• [Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.]
  • Egr-1 -> PTEN -> lower (AKT->mTOR)

Brain #

Important in Neuroplasticity/memory formation, i.e. VAMP2.