Ecdysteroid

links: Steroid reference: 7-26-2021

Ecdysteroid #

Turkesterone is one of a few forms (ecdysone, ecdysterone, and 2-deoxyecdysone) of it, not a band name. Synthesized from arthopods from choleterol, used for molting. Some people compare it to prolactin, but this comparison is controversial and seems to be wrong. According to Haidut’s research, the anabolic effects are connected with the acceleration of translocation processes, not the induction of new RNA synthesis. They act like classical steroids via cytoplasmic receptor and regulation of gene transcriptional activity. 20-hydroxyecysone does not have estrogenic or androgenic effects. It improves wound healing and improves skin conditions via thicckening skin.

• https://www.youtube.com/watch?v=66B-ZOVOARI
  • Activates ERβ
• https://raypeatforum.com/community/threads/spinach-contains-a-performance-enhancing-chemical.29568/post-440863
  • Caused liver enlargement, even in low doses!
  • Does not have anabolic effects in and of itself, but depends on endogenous steroids.
    • 20-Hydroxyecdysone resulted in weight gain in liver, heart, kidneys, and muscle (musculus tibilis anterior) in rats. This happens in estrogenic steroids like tren.
  • Activating the estrogen receptor can lead to proliferative disorders down the line
• Lots of virtues linked in this thread: https://raypeatforum.com/community/threads/plants-and-insects-as-a-source-of-steroids.20213/post-330254
  • Ecdysterone and turkesterone (5mg/kg) normalized NADH dehydrogenase and succinate dehydrogenase.
  • Inhibits apoptosis in osteroporotic rats
• Many in-depth explanations of its mechanisms: https://raypeatforum.com/community/threads/turkesterone.39302
  • Increases protein incorporation, adaptogenic, anti-arrhythmic, hepatopretective, lowers blood glucose, lowers cholesterol, anti-inflammatory, immune stimulant, spasmolytic, and wound healing.

Ecdysone #

https://raypeatforum.com/community/threads/plants-and-insects-as-a-source-of-steroids.20213/post-372958

• Effect of β‑ecdysterone on glucocorticoid‑induced apoptosis and autophagy in osteoblasts
• Ecdysone is highly homologous to aldosterone: it interacts with the mineralcorticoid receptor.
  • Increased cell apoptosis in the kidney, impaired renal function, and elicited early signs of renal fibrogenesis, marked by deposition of collagen and fibronectin in tubulointerstitium, reminiscent of the action of aldosterone.
  • Elicited cellular apoptosis and retarded cell motility, akin to the effect of aldosterone
• “induced mesenchymal accumulation of extracellular matrix and epithelial dedifferentiation characterized by de novo expression of α-smooth muscle actin.”

Supplementation #

Showed no toxicity in health markers when dose with 10mg per kg (760mg/day for me; Gorillamind is 500mg though??) Animal studies showed no toxicity as high as 20mg/kg.