CYP46A1

2022-08-09: reference:

CYP46A1 (Cholesterol 24-hydroxylase) #

Catalyzes conversion of cholesterol to 24S-hydroxycholesterol.

• Chapter Fourteen - Restoring synaptic function through multimodal therapeutics
  • Downregulates PSD-95 and SNAP 25 in mice.
  • Was not clear whether CYP46A1 activity was related to memory improvements through isoprenoid synthesis alone, or if its catalytic product 24-OH, had beneficial effects in synaptic proteins
• 24S-HYDROXYCHOLESTEROL EFFECTS ON LIPID METABOLISM GENES ARE MODELED IN TRAUMATIC BRAIN INJURY
  • CYP46A1 is upregulated after TBI. Increased SREBP-1 mRNA levels and decreased SREBP-2 mRNA.