Benzodiazepine

2022-09-04: reference:

Benzodiazepine #

• Benzos function by potentiating GABA-A. Chronic use causes downregulation+uncoupling, leading to increased extracellular GABA. Flumazenil then can cause upregulation of GABA-A once again.
• Excessive GABA release contributes to GABA-A internalization and release of Allopregnanolone.