p53
2022-02-24: reference:
- [p53: The Gene that Cracked the Cancer Code]
p53 (cellular tumor antigen p53, tumor suppressor p53, et al) #
- ‘Guardian of the genome’. Elevation in response to DNA damage can lead to apoptosis.
- Inducible (its transcription is stabilized by ROS, oncogenes, hypoxia, and DNA damage) and acts via upregulating p21; it is not a repressor. Buut apparently it has 350 target genes according to
https://tp53.isb-cgc.org/target_genes.
- Increases TIGAR expression, blocking glycolysis.