Adrenergic Receptor

2022-04-09: reference:

Adrenergic Receptor #

Noradrenaline binds to them, idk when it gets methylated to Adrenaline

• α1: Gq
  • Smooth muscle contraction of blood vessels, ureter, ductus deferens, and internal urethral sphincter.
  • Liver: glycogenolysis
  • Adipose tissue: Gluconeogenesis
  • Sweat gland secretion
  • α1A
  • α1B
  • α1C
  • α1D
• α2 Adrenergic Receptor: Gi
  • α2A
  • α2Β
• β1: Gs. Anxiolytic. Expressed in the heart.
• β2: Gs and Gi. Relaxation of the bladder. Lipolysis/thermogenesis in Brown Adipose. Found in muscle tissue moreso than the other β receptors.
• β3 Adrenegic Receptor: Gs and Gi. Shit’s complicated. Expressed in the bladder.
  • β3 agonism = relaxation of the bladder = peeing less, but a lot when you do.