Adiponectin

links: Hormones Adipose reference:

9-30-2021

Adiponectin #

• Levels rise during caloric restriction
• Decreased by Prolactin and Growth Hormone. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue
• Arctigenin is an AdipoR1 agonist that enhances SOD, Glutathione reductase, glutathione peroxidase, Thioredoxin, and UCP2.
• Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice
• Globular adiponectin acts as a melanogenic signal in human epidermal melanocytes
  • Demonstrated via AMPK inhibition abolishing this suppressive effect, i.e. preventing IL-1β maturation and caspase-1 activation.
• Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
  • FGF21 enhanced expression and secretion of adiponectin in adipocytes… adiponectin couples FGF21 actions in local adiopcytes to liver and skeletal muscle, thereby mediating the systemic effects of FGF21 on energy metabolism and insulin sensitivity.